All 17 Department of Energy (DOE) National Laboratories are using their resources to aid the fight against COVID-19 over the past few months. Argonne National Laboratory in Illinois, Oak Ridge National Laboratory in Tennessee, and Sandia National Laboratory in New Mexico have been working to better understand and stop further spread of the virus. Argonne National Lab has added a new “AI Supercomputer” to the efforts of the High Performance Computing Consortium working to support COVID-19 research, Oak Ridge is addressing supply chain challenges to testing swab production, and Sandra National Lab is using genetic sequencing tools to develop countermeasures to the virus. 7 of DOE’s 17 National Laboratories are working with the High Performance Computing Consortium to bring together the Federal government, industry, and academic leaders to provide access to the world’s most powerful high-performance computing resources in support of COVID-19 research. The new supercomputer, the DGX A100, is the fastest AI supercomputer being used by the consortium and has been in operation since May 9, 2020. It can screen an unprecedented 1 billion small molecule drugs a day with the hope that one will be able to be considered for use against corona virus.